Genetic association of HLA DQB1 with CD4+CD25+(high) T-cell apoptosis in type 1 diabetes. (Q51762715)

11 April 2018

title

Genetic association of HLA DQB1 with CD4+CD25+(high) T-cell apoptosis in type 1 diabetes. (English)

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11 April 2018

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S Glisic

1

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M Klinker

2

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J Waukau

3

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P Jailwala

4

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S Jana

5

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J Basken

6

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T Wang

7

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R Alemzadeh

8

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W Hagopian

9

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S Ghosh

10

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publication date

19 March 2009

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published in

Genes and Immunity

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volume

10

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issue

4

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page(s)

334-340

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https://scigraph.springernature.com/pub.10.1038/gene.2009.14

exact match

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CD8+ T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD SCID mouse.

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Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

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Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls

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At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction

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Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

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Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis.

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

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Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat

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CD8+ T-cells are required for adoptive transfer of the BB rat diabetic syndrome

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Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetes

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MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice

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HLA-DQ-restricted, islet-specific T-cell clones of a type I diabetic patient. T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice

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7 January 2021

T cell clones generated from patients with type 1 diabetes using interleukin-2 proliferate to human islet antigens

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MHC class II expression identifies functionally distinct human regulatory T cells

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Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

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7 January 2021

Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells

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Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis

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Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes

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7 January 2021

Molecular basis for HLA-DQ associations with IDDM.

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7 January 2021

Immune regulatory T cells in siblings of children suffering from type 1 diabetes mellitus

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7 January 2021

Seventeen-colour flow cytometry: unravelling the immune system

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7 January 2021

Identifiers

DOI

10.1038/GENE.2009.14

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11 April 2018

PubMed ID

19295543

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11 April 2018