Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes (Q37148316)

18 August 2017

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title

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes (English)

1 reference

18 August 2017

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1 reference

Pierre Pirot

1

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PubMed ID

18438526

18 August 2017

Alessandra K Cardozo

series ordinal

2

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PubMed ID

18438526

18 August 2017

Décio L Eizirik

series ordinal

3

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18 August 2017

1 March 2008

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Arquivos Brasileiros de Endocrinologia e Metabologia

18 August 2017

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18 August 2017

52

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18 August 2017

156-165

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18 August 2017

2

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https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

18 August 2017

1 reference

Cellular and molecular pathogenesis of type 1A diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

What can the HLA transgenic mouse tell us about autoimmune diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Autoantibodies in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Screening for insulitis in adult autoantibody-positive organ donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Environmental triggers and determinants of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Pancreatic islets under attack: cellular and molecular effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Viral infections as potential triggers of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Lessons on autoimmune diabetes from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Role of chemokines in endocrine autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Autoimmune destruction of pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Prevention of type 1 diabetes: from the view point of beta cell damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Contribution of Fas to diabetes development

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

The role of STATs in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Nitric oxide and peroxynitrite in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Molecular cloning and analysis of the human cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2) gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302008000200003

10.1590/S0004-27302008000200003

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18438526