Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α. (Q51766571)

11 April 2018

title

Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α. (English)

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11 April 2018

author name string

Jie Yu

1

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11 April 2018

Bing Yu

2

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Honglin Jiang

3

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11 April 2018

Daiwen Chen

4

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11 April 2018

publication date

18 July 2011

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British Journal of Nutrition

published in

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11 April 2018

volume

107

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issue

4

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page(s)

461-465

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Conjugated linoleic acid (CLA) and obesity.

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens

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The biologically active isomers of conjugated linoleic acid

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The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

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Fibroblast growth factor 21 corrects obesity in mice

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FGF-21 as a novel metabolic regulator

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PPARalpha is a key regulator of hepatic FGF21.

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Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver.

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

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Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

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Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

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Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins.

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

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Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.

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Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

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Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue

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Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes

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Conjugated linoleic acid reduces body fat accretion and lipogenic gene expression in neonatal pigs fed low- or high-fat formulas.

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Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes

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7 January 2021

10.1017/S0007114511003205

Identifiers

DOI

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11 April 2018

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11 April 2018