Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. (Q51811191)

12 April 2018

title

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. (English)

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12 April 2018

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Menglei Xia

1

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Di Huang

2

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Shanshan Li

3

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Jianping Wen

4

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Xiaoqiang Jia

5

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Yunlin Chen

6

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publication date

16 May 2013

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Biotechnology and Bioengineering

published in

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volume

110

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issue

10

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page(s)

2717-2730

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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

cites work

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Novel chemobiosynthetic approach for exclusive production of FK506.

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Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

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The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

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Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

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Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

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Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum

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Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture.

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Regulation of tacrolimus production by altering primary source of carbons and amino acids.

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Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae

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Quantification of sugar phosphate intermediates of the pentose phosphate pathway by LC-MS/MS: application to two new inherited defects of metabolism

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Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor

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MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis.

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Identifiers

DOI

10.1002/BIT.24941

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12 April 2018

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