Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. (Q34538163)

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English	Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.	scientific article

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18 January 2020

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues (English)

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18 January 2020

Bradley S. Moore

24

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18 January 2020

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SangJoon Mo

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18 January 2020

Dong Hwan Kim

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18 January 2020

Jong Hyun Lee

3

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18 January 2020

Je Won Park

4

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18 January 2020

Devi B Basnet

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18 January 2020

Yeon Hee Ban

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18 January 2020

Young Ji Yoo

7

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18 January 2020

Shu-wei Chen

8

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18 January 2020

Sung Ryeol Park

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18 January 2020

Eun Ae Choi

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18 January 2020

Eunji Kim

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18 January 2020

Ying-Yu Jin

12

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18 January 2020

Sung-Kwon Lee

13

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18 January 2020

Ju Yeol Park

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18 January 2020

Yuan Liu

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18 January 2020

Mi Ok Lee

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18 January 2020

Keum Soon Lee

17

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18 January 2020

Sang Jun Kim

18

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18 January 2020

Dooil Kim

19

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18 January 2020

Byoung Chul Park

20

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18 January 2020

Sang-gi Lee

21

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18 January 2020

Ho Jeong Kwon

22

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18 January 2020

Joo-Won Suh

23

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18 January 2020

Si-Kyu Lim

25

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18 January 2020

Yeo Joon Yoon

26

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18 January 2020

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22 December 2010

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18 January 2020

Journal of the American Chemical Society

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18 January 2020

133

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18 January 2020

4

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18 January 2020

976-985

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18 January 2020

Origin of the allyl group in FK506 biosynthesis

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7 July 2018

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

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7 July 2018

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

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7 July 2018

Biosynthesis of polyketide synthase extender units

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7 July 2018

Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants

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7 July 2018

Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome

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7 July 2018

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway

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7 July 2018

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

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7 July 2018

Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2).

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7 July 2018

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units

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7 July 2018

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

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7 July 2018

Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis

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7 July 2018

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

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7 July 2018

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

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7 July 2018

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

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Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

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7 July 2018

The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase.

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7 July 2018

Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

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7 July 2018

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

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7 July 2018

FK-506--a novel immunosuppressant

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7 July 2018

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

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7 July 2018

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP.

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27 October 2018

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27 October 2018

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

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27 October 2018

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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

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Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the N

1 reference

https://pubmed.ncbi.nlm.nih.gov/21175203

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA108399B

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18 January 2020

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18 January 2020

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18 January 2020

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