Cystathionine beta-synthase (Q5201183)

Tryptophan synthase beta subunit-like PLP-dependent enzyme

1 reference

CBS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Pyridoxal-phosphate dependent enzyme family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

NO* binds human cystathionine β-synthase quickly and tightly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

protein homodimerization activity

1 reference

8 April 2019

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

cystathionine beta-synthase activity

9 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 January 2018

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

3 references

26 September 2017

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

NO* binds human cystathionine β-synthase quickly and tightly

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

modified amino acid binding

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

S-adenosyl-L-methionine binding

1 reference

8 April 2019

Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

identical protein binding

4 references

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Shifted Transversal Design smart-pooling for high coverage interactome mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

1 reference

8 April 2019

Human cystathionine beta-synthase is a target for sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

pyridoxal phosphate binding

IPI

nitrite reductase (NO-forming) activity

1 reference

8 April 2019

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

ubiquitin protein ligase binding

1 reference

8 April 2019

Human cystathionine beta-synthase is a target for sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

NO* binds human cystathionine β-synthase quickly and tightly

IPI

carbon monoxide binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

cysteine synthase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

4 references

8 April 2019

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

NO* binds human cystathionine β-synthase quickly and tightly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

pyridoxal phosphate binding

3 references

8 April 2019

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

cystathionine beta-synthase activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

cysteine biosynthetic process via cystathionine

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

L-serine metabolic process

1 reference

8 April 2019

Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

1 reference

8 April 2019

Homocysteine contribution to DNA damage in cystathionine β-synthase-deficient patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

cellular amino acid biosynthetic process

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

L-serine catabolic process

1 reference

8 April 2019

Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

hydrogen sulfide biosynthetic process

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

homocysteine metabolic process

3 references

26 September 2017

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

26 September 2017

Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

L-cysteine catabolic process

1 reference

8 April 2019

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

cysteine biosynthetic process from serine

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35520&geneProductId=UniProtKB:P35520

homocysteine metabolic process

4 references

8 April 2019

Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

hydrogen sulfide biosynthetic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35520

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5136

Pyridoxal-phosphate dependent enzyme

English

retrieved

17 August 2016

has part(s)

1 reference

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

1 reference

CBS domain

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

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13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

1 reference

13 June 2020

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13 June 2020

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13 June 2020

1 reference

13 June 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference