Nuclear receptor subfamily 0 group B member 1 (Q5204362)

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mammalian protein found in Homo sapiens

truncated nuclear receptor subfamily 0 group B member 1
nuclear hormone receptor
DSS-AHC critical region on the X chromosome protein 1
nuclear receptor DAX-1
NR0B1
nuclear receptor subfamily 0 group B member 1

Language	Label	Description	Also known as
English	Nuclear receptor subfamily 0 group B member 1	mammalian protein found in Homo sapiens	truncated nuclear receptor subfamily 0 group B member 1 nuclear hormone receptor DSS-AHC critical region on the X chromosome protein 1 nuclear receptor DAX-1 NR0B1 nuclear receptor subfamily 0 group B member 1

Statements

1 reference

13 November 2019

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51843

Nuclear receptor subfamily 0 group B member 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51843

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Nuclear receptor repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein domain specific binding

determination method

1 reference

8 April 2019

Quantitative proteomics of the thyroid hormone receptor-coregulator interactions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

sequence-specific DNA binding

determination method

1 reference

24 April 2018

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

AF-2 domain binding

determination method

1 reference

24 April 2018

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

DNA hairpin binding

determination method

1 reference

8 April 2019

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

steroid hormone receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

protein binding

determination method

5 references

8 April 2019

Repressors of androgen and progesterone receptor action

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

transcription corepressor activity

determination method

3 references

8 April 2019

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

transcription factor binding

determination method

3 references

8 April 2019

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

determination method

9 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

24 April 2018

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

determination method

1 reference

8 April 2019

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

determination method

9 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

biological process

sex-determination system

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

spermatogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

24 April 2018

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

response to immobilization stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

pituitary gland development

determination method

1 reference

8 April 2019

Molecular mechanisms of DAX1 action

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

gonad development

determination method

1 reference

8 April 2019

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

Leydig cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

protein localization

determination method

1 reference

8 April 2019

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

hypothalamus development

determination method

1 reference

8 April 2019

Molecular mechanisms of DAX1 action

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

negative regulation of cell differentiation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

male sex determination

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

Sertoli cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

negative regulation of intracellular steroid hormone receptor signaling pathway

determination method

1 reference

8 April 2019

Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

steroid biosynthetic process

determination method

1 reference

8 April 2019

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

adrenal gland development

determination method

3 references

8 April 2019

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

negative regulation of transcription, DNA-templated

determination method

4 references

8 April 2019

DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

8 April 2019

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

intracellular receptor signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51843

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51843&geneProductId=UniProtKB:P51843

determination method

negative regulation of DNA-binding transcription factor activity

determination method

Gene Atlas image

PBB GE NR0B1 206644 at fs.png
732 × 530; 11 KB

0 references

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51843

Nuclear receptor repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51843

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000368253

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368253

ENSP00000368246

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368246

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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