Molecular mechanisms of DAX1 action (Q24306103)

Nuclear receptor subfamily 0 group B member 1

Europe PubMed Central

title

Molecular mechanisms of DAX1 action (English)

0 references

main subject

1 reference

pituitary gland development

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Anita K Iyer

series ordinal

1

0 references

Edward R B McCabe

series ordinal

2

0 references

language of work or name

English

0 references

publication date

2004

1 reference

Molecular Genetics and Metabolism

PubMed

published in

0 references

volume

83

0 references

issue

1-2

0 references

page(s)

60-73

0 references

cites work

Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin production

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Diagnosis of X-linked Adrenal Hypoplasia Congenita by Mutation Analysis of the DAX1 Gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1, an 'antitestis' gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Orphan nuclear receptors: from gene to function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Comparative localization of Dax-1 and Ad4BP/SF-1 during development of the hypothalamic-pituitary-gonadal axis suggests their closely related and distinct functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Steroidogenic factor 1: a key determinant of endocrine development and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX1 and its network partners: exploring complexity in development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Role of the LXXLL-motif and activation function 2 domain in subcellular localization of Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Repressors of androgen and progesterone receptor action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Nuclear receptor Dax-1 represses the transcriptional cooperation between GATA-4 and SF-1 in Sertoli cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Steroidogenic factor 1: an essential mediator of endocrine development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Steroidogenic factor-1 contains a carboxy-terminal transcriptional activation domain that interacts with steroid receptor coactivator-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX1 mutations map to putative structural domains in a deduced three-dimensional model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Novel receptor interaction and repression domains in the orphan receptor SHP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Down-Regulation of Steroidogenic Response to Gonadotropins in Human and Rat Preovulatory Granulosa Cells Involves Mitogen-Activated Protein Kinase Activation and Modulation of DAX-1 and Steroidogenic Factor-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Repression of DAX-1 and induction of SF-1 expression. Two mechanisms contributing to the activation of aldosterone biosynthesis in adrenal glomerulosa cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Protein kinase A potentiates adrenal 4 binding protein/steroidogenic factor 1 transactivation by reintegrating the subcellular dynamic interactions of the nuclear receptor with its cofactors, general control nonderepressed-5/transformation/transcrip

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Quantitative proteomics of the thyroid hormone receptor-coregulator interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

SRY interacts with and negatively regulates androgen receptor transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1 blocks steroid production at multiple levels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Role of Ahch in gonadal development and gametogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

SF-1, DAX-1, and acd: molecular determinants of adrenocortical growth and steroidogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Dax1 antagonizes Sry action in mammalian sex determination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Dax1 is required for testis determination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Dax1 regulates testis cord organization during gonadal differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

AMH/MIS: what we know already about the gene, the protein and its regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Hormonal and developmental regulation of DAX-1 expression in Sertoli cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Transcriptional profiling of human osteoblast differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Glycerol kinase deficiency with neuromuscular, skeletal, and adrenal abnormalities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1 Expression in Human Adrenocortical Neoplasms: Implications for Steroidogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: possible implications in steroidogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-alpha, ER-beta and androgen receptor status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

Nuclear receptor DAX‐1 in human common epithelial ovarian carcinoma: An independent prognostic factor of clinical outcome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2004.07.018

10.1016/J.YMGME.2004.07.018

7 January 2021

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

15464421

1 reference

Consolidated OpenCitations Corpus – April 2017