A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. (Q52133539)

22 April 2018

title

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. (English)

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22 April 2018

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1

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22 April 2018

Riccardo Fodde

10

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22 April 2018

Peter Devilee

9

object named as

Devilee P

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22 April 2018

Kielman MF

2

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22 April 2018

Breukel C

3

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22 April 2018

Bennett LM

4

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22 April 2018

Wiseman R

5

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22 April 2018

Krimpenfort P

6

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22 April 2018

Cornelisse C

7

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22 April 2018

van Ommen GJ

8

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22 April 2018

language of work or name

English

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publication date

1 May 2001

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22 April 2018

published in

Oncogene

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22 April 2018

volume

20

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22 April 2018

issue

20

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22 April 2018

page(s)

2544-2550

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22 April 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204363

exact match

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cites work

Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

A prospective trial of midwest breast cancer patients: a p53 gene mutation is the most important predictor of adverse outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

BRCA1 required for transcription-coupled repair of oxidative DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

BRCA1 protein products ... Functional motifs...

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Brca1 controls homology-directed DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

BRCA1 regulates p53-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Expression pattern of the mouse T gene and its role in mesoderm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

Transcriptional activation by BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

BRCA1 mutations and phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

7 January 2021

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

7 January 2021

Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

7 January 2021

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204363

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204363

1 reference

22 April 2018

1 reference

22 April 2018