Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity (Q28507875)

24 January 2017

title

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity (English)

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Eukaryotic elongation factor, selenocysteine-tRNA-specific

24 January 2017

1 reference

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

R. Smits

1

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24 January 2017

N. Hofland

2

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24 January 2017

W. Edelmann

3

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24 January 2017

M. Geugien

4

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24 January 2017

S. Jagmohan-Changur

5

1 reference

24 January 2017

C. Albuquerque

6

1 reference

24 January 2017

C. Breukel

7

1 reference

24 January 2017

R. Kucherlapati

8

1 reference

24 January 2017

M. F. Kielman

9

1 reference

24 January 2017

R. Fodde

10

1 reference

24 January 2017

publication date

1 November 2000

1 reference

Genes, Chromosomes and Cancer

24 January 2017

published in

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24 January 2017

volume

29

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24 January 2017

issue

3

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24 January 2017

page(s)

229–239

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

24 January 2017

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

21 January 2018

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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

21 January 2018

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Chain-terminating mutations in the APC gene lead to alterations in APC RNA and protein concentration

21 January 2018

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Identification and characterization of the familial adenomatous polyposis coli gene

21 January 2018

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

21 January 2018

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Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

21 January 2018

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Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

21 January 2018

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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

21 January 2018

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APC mutations occur early during colorectal tumorigenesis

21 January 2018

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MSH2 deficient mice are viable and susceptible to lymphoid tumours

21 January 2018

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Association of the APC gene product with beta-catenin

21 January 2018

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The APC gene product in normal and tumor cells

21 January 2018

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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

21 January 2018

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Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

21 January 2018

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Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

21 January 2018

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

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Association of the APC tumor suppressor protein with catenins

21 January 2018

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Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.

21 January 2018

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Beta-catenin: a key mediator of Wnt signaling

21 January 2018

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Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

21 January 2018

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10.1002/1098-2264(2000)9999:9999<::AID-GCC1033>3.0.CO;2-R

21 January 2018

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017