Probing the unfolding pathway of alpha1-antitrypsin. (Q52534363)

2 May 2018

title

Probing the unfolding pathway of alpha1-antitrypsin. (English)

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2 May 2018

author

James C Whisstock

2

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2 May 2018

Stephen P Bottomley

4

object named as

Bottomley SP

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2 May 2018

author name string

James EL

1

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2 May 2018

Gore MG

3

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2 May 2018

language of work or name

English

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publication date

1 April 1999

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2 May 2018

Journal of Biological Chemistry

published in

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2 May 2018

volume

274

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2 May 2018

issue

14

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2 May 2018

page(s)

9482-9488

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2 May 2018

Defective protein folding as a basis of human disease

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The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy.

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alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

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Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

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Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy

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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

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Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

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Detection and characterization of intermediates in the folding of large proteins by the use of genetically inserted tryptophan probes.

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A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation

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Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

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Perturbation of a tertiary hydrogen bond in barstar by mutagenesis of the sole His residue to Gln leads to accumulation of at least one equilibrium folding intermediate.

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How do small single-domain proteins fold?

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Major proteinase movement upon stable serpin-proteinase complex formation

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

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New insights into the structural basis of alpha 1-antitrypsin deficiency

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α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

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NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

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Defective protein folding as a cause of disease

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Folding pathway of human alpha 1-antitrypsin: characterization of an intermediate that is active but prone to aggregation

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Fluorescence-detected polymerization kinetics of human alpha 1-antitrypsin

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Preparation and characterization of latent alpha 1-antitrypsin

21 January 2018

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The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase

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Conformational changes in intact and papain-modified alpha 1-proteinase inhibitor induced by guanidinium chloride

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A thermostable mutation located at the hydrophobic core of alpha 1-antitrypsin suppresses the folding defect of the Z-type variant

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Effects of glycosylation on the folding and stability of human, recombinant and cleaved alpha 1-antitrypsin

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The stability and unfolding of an IgG binding protein based upon the B domain of protein A from Staphylococcus aureus probed by tryptophan substitution and fluorescence spectroscopy

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Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactive-site loop

21 January 2018

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Protein engineering of chimeric Serpins: an investigation into effects of the serpin scaffold and reactive centre loop length

21 January 2018

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Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

21 January 2018

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Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion

21 January 2018

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Unfolding free energy changes determined by the linear extrapolation method. 2. Incorporation of delta G degrees N-U values in a thermodynamic cycle.

21 January 2018

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Probing the native strain iin alpha1-antitrypsin

21 January 2018

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Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

21 January 2018

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Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.14.9482

1 reference

2 May 2018

PubMed ID

10092631

1 reference

2 May 2018