Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. (Q52680647)

5 May 2018

title

Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. (English)

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5 May 2018

author name string

Jeremiah W Hanes

1

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5 May 2018

Yali Zhu

2

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5 May 2018

Deborah S Parris

3

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5 May 2018

Kenneth A Johnson

4

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5 May 2018

language of work or name

English

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publication date

14 June 2007

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5 May 2018

Journal of Biological Chemistry

published in

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5 May 2018

volume

282

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5 May 2018

issue

34

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5 May 2018

page(s)

25159-25167

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5 May 2018

The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Reproduced from Proc. Natl. Acad. Sci. USA 74, 5716-5720 (1977)

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Contribution of the 3'- to 5'-exonuclease activity of herpes simplex virus type 1 DNA polymerase to the fidelity of DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Conformational coupling in DNA polymerase fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Adverse effects of antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Mitochondrial toxicity of antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Mutations within conserved motifs in the 3'-5' exonuclease domain of herpes simplex virus DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Slow rate of phosphodiester bond formation accounts for the strong bias that Taq DNA polymerase shows against 2',3'-dideoxynucleotide terminators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Nucleoside reverse transcriptase inhibitor usage and the incidence of peripheral neuropathy in HIV/AIDS patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703972200

21 January 2018

Identifiers

DOI

10.1074/JBC.M703972200

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5 May 2018

1 reference

5 May 2018