Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy. (Q52714310)

6 May 2018

title

Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy. (English)

1 reference

6 May 2018

Eveline Lescrinier

3

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Piet Herdewijn

object named as

Piet Herdewijn

series ordinal

4

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author name string

Mohitosh Maiti

series ordinal

1

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6 May 2018

Koen Nauwelaerts

series ordinal

2

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6 May 2018

language of work or name

English

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publication date

5 January 2011

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6 May 2018

Chemistry—A European Journal

published in

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6 May 2018

volume

17

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6 May 2018

issue

5

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6 May 2018

page(s)

1519-1528

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6 May 2018

describes a project that uses

1 reference

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

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Argonaute proteins: key players in RNA silencing

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Crystal structure of Argonaute and its implications for RISC slicer activity

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Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

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Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

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Structure of the guide-strand-containing argonaute silencing complex

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Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

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Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

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Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

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https://api.crossref.org/works/10.1002%2FCHEM.201000765

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

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The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

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Structure and conserved RNA binding of the PAZ domain

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Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis

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A three-dimensional view of the molecular machinery of RNA interference

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Solution structure of a HNA-RNA hybrid

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Crystal structure of double helical hexitol nucleic acids

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Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

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Synthesis of D-altritol nucleosides with a 3'-O-tert-butyldimethylsilyl protecting group

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Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides

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Inhibition of MDR1 expression with altritol-modified siRNAs

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The Xplor-NIH NMR molecular structure determination package

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3' overhang regions and their ability to suppress human RNase L protein expression

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

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Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

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Conformation of double-stranded polydeoxynucleotides in solution by proton two-dimensional nuclear Overhauser enhancement spectroscopy.

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A general enhancement scheme in heteronuclear multidimensional NMR employing pulsed field gradients

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1 reference

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Conformational and helicoidal analysis of 30 PS of molecular dynamics on the d(CGCGAATTCGCG) double helix: "curves", dials and windows.

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21 January 2018

Identifiers

DOI

10.1002/CHEM.201000765

1 reference

6 May 2018

1 reference

6 May 2018