Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook (Q37665372)

21 August 2017

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title

Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook (English)

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21 August 2017

Siddharth Shukla

1

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21 August 2017

Chintan S Sumaria

series ordinal

2

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21 August 2017

P I Pradeepkumar

series ordinal

3

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21 August 2017

publication date

1 March 2010

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21 August 2017

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21 August 2017

volume

5

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21 August 2017

issue

3

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21 August 2017

page(s)

328-349

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Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

21 August 2017

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Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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Lentiviral-mediated delivery of siRNAs for antiviral therapy

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7 January 2021

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

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7 January 2021

Structural insights into RNA processing by the human RISC-loading complex

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7 January 2021

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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7 January 2021

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

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7 January 2021

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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Argonaute2 is the catalytic engine of mammalian RNAi

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7 January 2021

Small RNAs: regulators and guardians of the genome

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7 January 2021

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

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7 January 2021

Identification of novel argonaute-associated proteins

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7 January 2021

Origins and Mechanisms of miRNAs and siRNAs

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The roles of microRNA in cancer and apoptosis

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7 January 2021

Micromanipulating cancer: microRNA-based therapeutics?

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7 January 2021

https://api.crossref.org/works/10.1002%2FCMDC.200900444

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7 January 2021

Purified Argonaute2 and an siRNA form recombinant human RISC

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Slicer and the argonautes

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Structural and functional modules in RNA interference

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7 January 2021

Argonaute proteins: key players in RNA silencing

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7 January 2021

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

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7 January 2021

Crystal structure of Argonaute and its implications for RISC slicer activity

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RISC is a 5' phosphomonoester-producing RNA endonuclease

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7 January 2021

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage

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7 January 2021

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

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7 January 2021

Retroviral integrase superfamily: the structural perspective

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7 January 2021

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

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7 January 2021

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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7 January 2021

A three-dimensional view of the molecular machinery of RNA interference

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7 January 2021

Molecular basis for target RNA recognition and cleavage by human RISC.

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7 January 2021

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Argonaute: A scaffold for the function of short regulatory RNAs

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNAi in human cells: basic structural and functional features of small interfering RNA.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA function in RNAi: a chemical modification analysis

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Tolerance for mutations and chemical modifications in a siRNA.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Kinetic analysis of the RNAi enzyme complex

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Illuminating the silence: understanding the structure and function of small RNAs

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Potent RNAi by short RNA triggers.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Perspective: machines for RNAi

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Developments in RNA chemistry, a personal view

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7 January 2021

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

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7 January 2021

Hypoxia reduces constitutive and TNF-alpha-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells.

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7 January 2021

Nucleoside and oligonucleoside boranophosphates: chemistry and properties

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7 January 2021

RNA interference using boranophosphate siRNAs: structure-activity relationships

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

High potency silencing by single-stranded boranophosphate siRNA.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference in mammalia cells by RNA-3'-PNA chimeras

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference tolerates 2'-fluoro modifications at the Argonaute2 cleavage site.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference in mammalian cells by chemically-modified RNA.

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Steric effects in RNA interference: probing the influence of nucleobase size and shape.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA major groove modifications improve siRNA stability and biological activity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The RNA-induced silencing complex: a versatile gene-silencing machine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Synthetic shRNAs as potent RNAi triggers.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Analysis of siRNA specificity on targets with double-nucleotide mismatches

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Specificity of microRNA target selection in translational repression

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Comparison of siRNA-induced off-target RNA and protein effects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Experimental validation of the importance of seed complement frequency to siRNA specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Off-target effects by siRNA can induce toxic phenotype

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Chemical modifications rescue off-target effects of RNAi

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Designing siRNA that distinguish between genes that differ by a single nucleotide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Tolerance of RNA interference toward modifications of the 5' antisense phosphate of small interfering RNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Improved silencing properties using small internally segmented interfering RNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA and innate immunity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

How cells respond to interferons

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https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

5'-Triphosphate RNA is the ligand for RIG-I

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Cationic lipids enhance siRNA-mediated interferon response in mice.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Cationic liposome-mediated delivery of siRNAs in adult mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Modifications in small interfering RNA that separate immunostimulation from RNA interference

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

2'-O-methyl-modified RNAs act as TLR7 antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA binding proteins of microglial cells: PKR is an unanticipated ligand.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Protection against lethal influenza virus challenge by RNA interference in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Inhibition of influenza virus production in virus-infected mice by RNA interference

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNAs: their potential as therapeutic agents--Part II. Methods of delivery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Knocking down barriers: advances in siRNA delivery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA relieves chronic neuropathic pain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNAs: applications in functional genomics and potential as therapeutics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Biodistribution of phosphodiester and phosphorothioate siRNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Factors affecting the clearance and biodistribution of polymeric nanoparticles.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Extracellular matrix glycoproteins and diffusion barriers in human astrocytic tumours

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The in vitro kinetics of the interactions between PEG-ylated magnetic-fluid-loaded liposomes and macrophages.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Retroviral vectors: new applications for an old tool

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Antisense oligodeoxynucleotide-conjugated hyaluronic acid/protamine nanocomplexes for intracellular gene inhibition.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNAi-mediated gene silencing in non-human primates.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Development of lipidoid-siRNA formulations for systemic delivery to the liver

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Delivery of short interfering RNA using endosomolytic cell-penetrating peptides.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Polyethylenimine-based non-viral gene delivery systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Polymers for gene delivery across length scales.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Gene transfer with modified polyethylenimines

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Aptamer mediated siRNA delivery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Transvascular delivery of small interfering RNA to the central nervous system.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

siRNA delivery using peptide transduction domains

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The promises and pitfalls of RNA-interference-based therapeutics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

The impact of target site accessibility on the design of effective siRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Innate immunity confounds the clinical efficacy of small interfering RNAs (siRNAs).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900444

7 January 2021

Identifiers

DOI

10.1002/CMDC.200900444

1 reference

21 August 2017

1 reference