Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice. (Q53060638)

11 May 2018

title

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice. (English)

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11 May 2018

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Takeo Toshima

1

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11 May 2018

Ken Shirabe

2

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11 May 2018

Takasuke Fukuhara

3

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11 May 2018

Toru Ikegami

4

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11 May 2018

Tomoharu Yoshizumi

5

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11 May 2018

Yuji Soejima

6

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11 May 2018

Tetsuo Ikeda

7

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11 May 2018

Shinji Okano

8

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11 May 2018

Yoshihiko Maehara

9

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11 May 2018

language of work or name

English

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publication date

6 May 2014

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11 May 2018

published in

Hepatology

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11 May 2018

volume

60

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11 May 2018

page(s)

290-300

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11 May 2018

issue

1

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11 May 2018

Underlying potential: cellular and molecular determinants of adult liver repair

cites work

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A novel role of nucleostemin in maintaining the genome integrity of dividing hepatocytes during mouse liver development and regeneration

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Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice

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AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression

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Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration.

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Autophagy: renovation of cells and tissues

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Autophagosomes form at ER-mitochondria contact sites

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

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MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Inducible gene targeting in mice

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Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice

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An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure

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MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration

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Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration

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The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.

21 January 2018

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PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival

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Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast

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Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction

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Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

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IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence

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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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Management of multicellular senescence and oxidative stress

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Probing the depths of cellular senescence

21 January 2018

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Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice.

21 January 2018

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Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice

21 January 2018

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Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism

21 January 2018

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The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy

21 January 2018

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Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

21 January 2018

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

21 January 2018

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The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

21 January 2018

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Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential botanical drug

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/HEP.27140

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11 May 2018

PubMed ID

24668739

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11 May 2018