Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28. (Q53131392)

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scientific article published on 21 November 2012

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English	Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28.	scientific article published on 21 November 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

Christer Halldin

4

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Christer Halldin

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Europe PubMed Central

PubMed publication ID

11 May 2018

author name string

Nahid Amini

1

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

Ryuji Nakao

2

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

Magnus Schou

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11 May 2018

http://europepmc.org/abstract/MED/23180082

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publication date

21 November 2012

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11 May 2018

http://europepmc.org/abstract/MED/23180082

Analytical and Bioanalytical Chemistry

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PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

405

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

4

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11 May 2018

http://europepmc.org/abstract/MED/23180082

1303-1310

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

Analyses of [(18)F]altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans.

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Characterization of the radioactive metabolites of the 5-HT1A receptor radioligand, [O-methyl-11C]WAY-100635, in monkey and human plasma by HPLC: comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey u

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Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635--explanation of high signal contrast in PET and an aid to biomathematical modelling.

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Applications of LC-MS in PET radioligand development and metabolic elucidation

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Synthesis, radiolabeling and preliminary in vivo evaluation of [18F]FE-PE2I, a new probe for the dopamine transporter.

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Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY.

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Enhanced metabolite identification with MS(E) and a semi-automated software for structural elucidation

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Plasma pharmacokinetics and metabolism of the benzodiazepine antagonist [11C] Ro 15-1788 (flumazenil) in baboon and human during positron emission tomography studies.

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In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.

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Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation

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Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors

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PET radiotracers: crossing the blood-brain barrier and surviving metabolism

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Comparison of in vitro preparations for semi-quantitative prediction of in vivo drug metabolism

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10.1007/S00216-012-6541-2

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23180082

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