Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. (Q53155431)

11 May 2018

title

Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. (English)

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11 May 2018

human embryonic stem cell

main subject

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3

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Nevila Hyka-Nouspikel

1

object named as

Nevila Hyka-Nouspikel

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author name string

Joëlle Desmarais

2

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Mark Jones

4

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Mark Meuth

5

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Peter W Andrews

6

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Thierry Nouspikel

7

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publication date

1 September 2012

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published in

Stem Cells

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volume

30

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issue

9

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page(s)

1901-1910

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Core transcriptional regulatory circuitry in human embryonic stem cells

cites work

1 reference

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

21 January 2018

1 reference

Surface antigens of human embryonic stem cells: changes upon differentiation in culture

21 January 2018

1 reference

Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

21 January 2018

1 reference

Clonal tracking of hESCs reveals differential contribution to functional assays

21 January 2018

1 reference

Stem cell states, fates, and the rules of attraction

21 January 2018

1 reference

Aneuploidy and early human embryo development

21 January 2018

1 reference

Preimplantation genetic diagnosis for aneuploidy screening in early human embryos: a review

21 January 2018

1 reference

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

21 January 2018

1 reference

The tumorigenicity of diploid and aneuploid human pluripotent stem cells

21 January 2018

1 reference

From teratocarcinomas to embryonic stem cells

21 January 2018

1 reference

Hypoxia causes downregulation of mismatch repair system and genomic instability in stem cells

21 January 2018

1 reference

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

21 January 2018

1 reference

Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells

21 January 2018

1 reference

Molecular mechanisms of mammalian global genome nucleotide excision repair.

21 January 2018

1 reference

DNA damage recognition during nucleotide excision repair in mammalian cells

21 January 2018

1 reference

DNA repair in differentiated cells: some new answers to old questions

21 January 2018

1 reference

DNA repair in mammalian cells : Nucleotide excision repair: variations on versatility

21 January 2018

1 reference

DNA repair in terminally differentiated cells

21 January 2018

1 reference

Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression

21 January 2018

1 reference

Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation

21 January 2018

1 reference

Transcription domain-associated repair in human cells

21 January 2018

1 reference

Nucleotide excision repair and B lymphoma: somatic hypermutation is not the only culprit.

21 January 2018

1 reference

Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme

21 January 2018

1 reference

Multiple roles of ubiquitination in the control of nucleotide excision repair

21 January 2018

1 reference

Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro

21 January 2018

1 reference

Role of DNA polymerase eta in the UV mutation spectrum in human cells

21 January 2018

1 reference

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

21 January 2018

1 reference

Embryonic stem cell lines derived from human blastocysts

21 January 2018

1 reference

Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system.

21 January 2018

1 reference

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

21 January 2018

1 reference

Oct-4 controls cell-cycle progression of embryonic stem cells

21 January 2018

1 reference

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

21 January 2018

1 reference

Translesion synthesis: Y-family polymerases and the polymerase switch

21 January 2018

1 reference

Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair

21 January 2018

1 reference

The human intra-S checkpoint response to UVC-induced DNA damage

21 January 2018

1 reference

Inhibition of the ubiquitin-proteasome system induces stress granule formation.

21 January 2018

1 reference

Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate

21 January 2018

1 reference

p21 in cancer: intricate networks and multiple activities

21 January 2018

1 reference

Cell cycle features of primate embryonic stem cells.

21 January 2018

1 reference

Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.

21 January 2018

1 reference

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

21 January 2018

1 reference

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

1 reference

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

21 January 2018

1 reference

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

21 January 2018

1 reference

Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants

21 January 2018

1 reference

Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

21 January 2018

1 reference

DNA damage responses in human induced pluripotent stem cells and embryonic stem cells

21 January 2018

1 reference

p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

21 January 2018

1 reference

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

21 January 2018

1 reference

Instability and decay of the primary structure of DNA

21 January 2018

1 reference

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

1 reference

Sept4/ARTS is required for stem cell apoptosis and tumor suppression

21 January 2018

1 reference

Beyond tumorigenesis: cancer stem cells in metastasis

21 January 2018

1 reference

Cancer stem cells: controversial or just misunderstood?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1177

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11 May 2018

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11 May 2018