Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis. (Q53191116)

12 May 2018

title

Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis. (English)

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12 May 2018

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Valentina Iadevaia

object named as

Valentina Iadevaia

1

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Yilin Huo

2

object named as

Yilin Huo

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12 May 2018

Leonard J Foster

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object named as

Leonard J Foster

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12 May 2018

author name string

Ze Zhang

3

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12 May 2018

publication date

1 February 2012

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Biochemical Society Transactions

published in

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12 May 2018

volume

40

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issue

1

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12 May 2018

page(s)

168-172

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12 May 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

cites work

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https://api.crossref.org/works/10.1042%2FBST20110682

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Activation of mTORC2 by association with the ribosome

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110682

Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

TORC1 association with rDNA chromatin as a mechanism to co-regulate Pol I and Pol III.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

mTORC1 directly phosphorylates and regulates human MAF1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110682

21 January 2018

Identifiers

DOI

10.1042/BST20110682

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12 May 2018

PubMed ID

22260684

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12 May 2018