A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. (Q53224745)

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scientific article published on 19 January 2015

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English	A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.	scientific article published on 19 January 2015

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12 May 2018

http://europepmc.org/abstract/MED/25601637

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. (English)

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12 May 2018

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Fabian J. Theis

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Mert Erkan

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Anna Melissa Schlitter

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Irene Esposito

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Christoph W Michalski

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Jens T Siveke

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Carsten Jäger

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Philipp Bruns

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Nora Behler

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Ziying Jian

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Bo Kong

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Weiwei Wu

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Tao Cheng

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Johannes Beckers

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Andrea Tannapfel

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Jörg Kleeff

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19 January 2015

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A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Climbing RAS, the Everest of Oncogenes

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

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PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

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21 January 2018

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

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21 January 2018

TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

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TSC1 involvement in bladder cancer: diverse effects and therapeutic implications

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Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

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21 January 2018

Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells

1 reference

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21 January 2018

Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer

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21 January 2018

Targeting mTOR dependency in pancreatic cancer

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21 January 2018

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas

1 reference

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21 January 2018

C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer

1 reference

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21 January 2018

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

1 reference

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21 January 2018

Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer

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21 January 2018

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.

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Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

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The aldehyde dehydrogenase gene superfamily resource center

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Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform

1 reference

https://api.crossref.org/works/10.1136%2FGUTJNL-2014-307616

21 January 2018

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

1 reference

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ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools

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Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development

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Identifiers

10.1136/GUTJNL-2014-307616

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/25601637

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/25601637

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