Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling (Q37725691)

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13 March 2020

title

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling (English)

1 reference

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13 March 2020

1 reference

1 reference

15

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Elvin Wagenblast

5

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Jian-min Wu

13

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Sean Grimmond

14

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Andrew Biankin

17

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16

Carol Prives

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13 March 2020

author name string

Susann Weissmueller

1

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13 March 2020

Eusebio Manchado

2

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13 March 2020

Michael Saborowski

3

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13 March 2020

John P Morris

4

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13 March 2020

Carrie A Davis

6

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Sung-Hwan Moon

7

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Neil T Pfister

8

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Darjus F Tschaharganeh

9

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Thomas Kitzing

10

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Daniela Aust

11

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13 March 2020

Elke K Markert

12

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Scott W Lowe

18

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13 March 2020

language of work or name

English

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publication date

1 April 2014

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13 March 2020

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13 March 2020

volume

157

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issue

2

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page(s)

382-394

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Phase I/II trial of capecitabine and oxaliplatin in combination with bevacizumab and imatinib in patients with metastatic colorectal cancer: AIO KRK 0205.

13 March 2020

cites work

1 reference

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MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

23 August 2017

1 reference

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Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.

23 August 2017

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Mutant p53 drives invasion in breast tumors through up-regulation of miR-155.

23 August 2017

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Mutant p53: one name, many proteins

23 August 2017

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

23 August 2017

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TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

23 August 2017

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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

23 August 2017

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Platelet-derived growth factor receptor tyrosine kinase inhibitors: a review of the recent patent literature

23 August 2017

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

23 August 2017

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The first 30 years of p53: growing ever more complex

23 August 2017

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Phase I study of the safety, tolerability, and pharmacokinetics of oral CP-868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers

23 August 2017

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

23 August 2017

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

23 August 2017

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Structural biology of the tumor suppressor p53 and cancer-associated mutants

23 August 2017

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Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

23 August 2017

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

23 August 2017

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TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

23 August 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

23 August 2017

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PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells.

23 August 2017

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6 September 2017

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3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

6 September 2017

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6 September 2017

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p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.

6 September 2017

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6 September 2017

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6 September 2017

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

6 September 2017

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Mutant p53 drives invasion by promoting integrin recycling

6 September 2017

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Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.

14 September 2017

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Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function

14 September 2017

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The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia

14 September 2017

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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

14 September 2017

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

1 September 2018

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Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24725405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24725405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2014.01.066

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24725405%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24725405%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

24725405

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24725405%20AND%20SRC:MED&resulttype=core&format=json