B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. (Q53271931)

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scientific article published on 3 April 2012

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English	B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells.	scientific article published on 3 April 2012

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27 January 2020

B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells (English)

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27 January 2020

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Marie-Pierre Puissegur

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Cyril Broccardo

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Florence Nguyen-Khac

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Marina Bousquet

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R Eichner

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C Quelen

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K Lebrigand

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P Brousset

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publication date

3 April 2012

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2224-2232

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https://scigraph.springernature.com/pub.10.1038/leu.2012.95

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MicroRNA-125b is a novel negative regulator of p53.

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The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development.

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Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells

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Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A.

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Eμ/miR-125b transgenic mice develop lethal B-cell malignancies.

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The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations

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Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia

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10.1038/LEU.2012.95

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27 January 2020

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27 January 2020

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