Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. (Q53283775)

13 May 2018

title

Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe. (English)

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13 May 2018

co-transcriptional gene silencing by RNA interference machinery

main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0033562

Schizosaccharomyces pombe

object named as

Schizosaccharomyces pombe

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3

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13 May 2018

Marc Buehler

object named as

Marc Bühler

series ordinal

4

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author name string

Katrina J Woolcock

series ordinal

1

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13 May 2018

Dimos Gaidatzis

series ordinal

2

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13 May 2018

publication date

12 December 2010

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13 May 2018

Nature Structural & Molecular Biology

published in

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13 May 2018

volume

18

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13 May 2018

issue

1

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13 May 2018

page(s)

94-99

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/nsmb.1935

exact match

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cites work

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Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing.

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Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.

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Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs.

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RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production

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A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe

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siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription

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Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

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RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing

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A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.

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Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast

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2 references

https://pubmed.ncbi.nlm.nih.gov/21151114

21 January 2018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast

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21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21151114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Centromeric chromatin in fission yeast

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21151114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1935

1 reference

13 May 2018

PubMed ID

21151114

1 reference

13 May 2018