Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173. (Q53291157)

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scientific article published on 4 November 2010

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English	Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173.	scientific article published on 4 November 2010

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

cervix uterine cancer

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inferred from title

author name string

Lu Kong

1

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

Zhihong Deng

2

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

Haiying Shen

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

Yuxiang Zhang

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

publication date

4 November 2010

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

Molecular and Cellular Biochemistry

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

348

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PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

1-2

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

11-19

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Both EGFR kinase and Src-related tyrosine kinases regulate human ether-à-go-go-related gene potassium channels

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Src in cancer: deregulation and consequences for cell behaviour

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Targeting EGFR resistance networks in head and neck cancer.

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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EGFR mutations and EGFR tyrosine kinase inhibition in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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inferred from PubMed ID database lookup

Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Cell cycle control of DNA replication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Effects of different combinations of gefitinib and irinotecan in lung cancer cell lines expressing wild or deletional EGFR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Cellular functions regulated by Src family kinases

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https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Epidemiologic classification of human papillomavirus types associated with cervical cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor: mechanisms of activation and signalling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Epidermal growth factor receptor (EGFR) signaling in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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The pp60c-Src inhibitor PP1 is non-competitive against ATP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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The complexity of targeting EGFR signalling in cancer: from expression to turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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An in vitro chemosensitivity test for the screening of anti-cancer drugs in childhood leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Src inhibitors: drugs for the treatment of osteoporosis, cancer or both?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Anti-EGFR activation, anti-proliferative and pro-apoptotic effects of polyclonal antibodies induced by EGFR-based cancer vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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inferred from PubMed ID database lookup

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

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c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SRC family kinases mediate epithelial Na+ channel inhibition by endothelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21052789

12 December 2020

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Identifiers

10.1007/S11010-010-0632-1

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21052789

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