EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. (Q53292368)

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scientific article published on 12 December 2010

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English	EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis.	scientific article published on 12 December 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. (English)

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

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based on heuristic

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phosphorylation

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based on heuristic

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based on heuristic

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author name string

Steffen Heeg

1

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Nina Hirt

2

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Angela Queisser

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Hannah Schmieg

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Michaela Thaler

5

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Heike Kunert

6

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Michael Quante

7

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Gitta Goessel

8

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Alexander von Werder

9

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Jan Harder

10

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Roderick Beijersbergen

11

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Hubert E Blum

12

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Hiroshi Nakagawa

13

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Oliver G Opitz

14

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

publication date

12 December 2010

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

102

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13 May 2018

http://europepmc.org/abstract/MED/21156006

2

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http://europepmc.org/abstract/MED/21156006

351-360

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

1 reference

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Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

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21 January 2018

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

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Creation of human tumour cells with defined genetic elements

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Immortalization and transformation of primary human airway epithelial cells by gene transfer.

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Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

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21 January 2018

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

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21 January 2018

Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis.

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21 January 2018

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

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21 January 2018

Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?

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21 January 2018

Regulation of the human telomerase reverse transcriptase gene

1 reference

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21 January 2018

Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

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21 January 2018

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

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Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism

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21 January 2018

Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

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21 January 2018

Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells

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21 January 2018

Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines

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21 January 2018

Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms

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21 January 2018

HIF-1-mediated activation of telomerase in cervical cancer cells

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21 January 2018

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

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21 January 2018

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells

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21 January 2018

Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism

1 reference

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21 January 2018

Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway

1 reference

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21 January 2018

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

1 reference

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21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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21 January 2018

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2010.01796.X

21 January 2018

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2010.01796.X

21 January 2018

A genetically defined model for human ovarian cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2010.01796.X

21 January 2018

Rules for making human tumor cells

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https://api.crossref.org/works/10.1111%2FJ.1349-7006.2010.01796.X

21 January 2018

Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2010.01796.X

21 January 2018

hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

1 reference

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21 January 2018

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

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Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications

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The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

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Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

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Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

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Identifiers

10.1111/J.1349-7006.2010.01796.X

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/21156006

ResearchGate publication ID

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