Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. (Q53303993)

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5 February 2020

title

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway (English)

1 reference

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5 February 2020

9

Christian Haass

1 reference

PubMed publication ID

19692615

13 May 2018

http://europepmc.org/abstract/MED/19692615

Jochen Herms

10

object named as

Jochen Herms

1 reference

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5 February 2020

3

Steffen Burgold

1 reference

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5 February 2020

9

Christian Haass

1 reference

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5 February 2020

8

Hans A Kretzschmar

1 reference

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2

Martin Fuhrmann

1 reference

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5 February 2020

7

Gerda Mitteregger

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5 February 2020

author name string

Tobias Bittner

1

1 reference

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5 February 2020

Christian K E Jung

4

1 reference

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Christiane Volbracht

5

1 reference

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Harald Steiner

6

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language of work or name

English

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publication date

1 August 2009

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5 February 2020

published in

Journal of Neuroscience

1 reference

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volume

29

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issue

33

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page(s)

10405-10409

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describes a project that uses

5 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

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12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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An image analysis algorithm for dendritic spines

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A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

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Alzheimer's disease is a synaptic failure

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Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

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Long-term dendritic spine stability in the adult cortex

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12 December 2020

The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

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12 December 2020

APP processing and synaptic function

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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12 December 2020

Gamma-secretase: proteasome of the membrane?

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12 December 2020

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

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12 December 2020

Transient and persistent dendritic spines in the neocortex in vivo

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12 December 2020

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex

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12 December 2020

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

1 reference

12 December 2020

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

Remodeling of synaptic structure in sensory cortical areas in vivo.

1 reference

12 December 2020

Experience-dependent and cell-type-specific spine growth in the neocortex.

1 reference

12 December 2020

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

1 reference

12 December 2020

Spine growth precedes synapse formation in the adult neocortex in vivo.

1 reference

12 December 2020

AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

1 reference

12 December 2020

Dendritic pathology in prion disease starts at the synaptic spine.

1 reference

12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

12 December 2020

Presenilin: running with scissors in the membrane

1 reference

12 December 2020

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

1 reference

12 December 2020

Alzheimer's disease: a central role for amyloid

1 reference

12 December 2020

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

1 reference

12 December 2020

10.1523/JNEUROSCI.2288-09.2009

Identifiers

DOI

1 reference

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5 February 2020

1 reference

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5 February 2020

PubMed publication ID

19692615

1 reference