Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration (Q28590719)

31 January 2017

title

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration (English)

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31 January 2017

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GOA release 2020-03-11

Presenilin 1

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GOA release 2020-03-11

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11

Alfredo Kirkwood

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31 January 2017

Carlos A. Saura

1

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31 January 2017

Se-Young Choi

2

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31 January 2017

Vassilios Beglopoulos

3

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31 January 2017

Seema Malkani

4

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31 January 2017

Dawei Zhang

5

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31 January 2017

B. S. Shankaranarayana Rao

6

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31 January 2017

Sumantra Chattarji

7

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31 January 2017

Raymond J. Kelleher

8

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31 January 2017

Eric R. Kandel

9

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31 January 2017

Karen Duff

10

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31 January 2017

Jie Shen

12

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31 January 2017

language of work or name

English

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publication date

8 April 2004

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31 January 2017

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31 January 2017

volume

42

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31 January 2017

issue

1

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31 January 2017

page(s)

23–36

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A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

31 January 2017

cites work

1 reference

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7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

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7 January 2021

A synaptic model of memory: long-term potentiation in the hippocampus

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7 January 2021

Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn

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7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

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7 January 2021

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

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7 January 2021

Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease

1 reference

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS.

1 reference

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7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

The presenilins and Alzheimer's disease

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7 January 2021

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

APP processing and synaptic function

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7 January 2021

The molecular biology of memory storage: a dialogue between genes and synapses

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7 January 2021

NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vitro.

1 reference

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7 January 2021

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

The presenilin 1 C92S mutation increases abeta 42 production.

1 reference

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7 January 2021

The molecular basis of CaMKII function in synaptic and behavioural memory

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7 January 2021

Function and regulation of CREB family transcription factors in the nervous system

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Disruption of CREB function in brain leads to neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

NMDA receptor-mediated control of protein synthesis at developing synapses.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

1 reference

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Protein synthesis at synaptic sites on dendrites

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism

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https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Is CREB a key to neuronal survival?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2804%2900182-5

7 January 2021

10.1016/S0896-6273(04)00182-5

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017