A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals. (Q53364532)

13 May 2018

title

A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals. (English)

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13 May 2018

author name string

Yuu Taguchi

1

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13 May 2018

Jin Gohda

2

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13 May 2018

Takako Koga

3

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13 May 2018

Hiroshi Takayanagi

4

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13 May 2018

Jun-ichiro Inoue

5

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13 May 2018

publication date

20 October 2009

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13 May 2018

published in

Genes to Cells

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13 May 2018

volume

14

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13 May 2018

issue

11

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13 May 2018

page(s)

1331-1345

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13 May 2018

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

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Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.

21 January 2018

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Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

21 January 2018

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RANK is essential for osteoclast and lymph node development

21 January 2018

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The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily

21 January 2018

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RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.

21 January 2018

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

21 January 2018

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Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling

21 January 2018

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Self-assembled RANK induces osteoclastogenesis ligand-independently.

21 January 2018

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Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice

21 January 2018

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Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis

21 January 2018

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Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

21 January 2018

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.

21 January 2018

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

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Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis

21 January 2018

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 January 2018

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PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

21 January 2018

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Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

21 January 2018

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21 January 2018

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Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

21 January 2018

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

21 January 2018

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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

21 January 2018

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Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts

21 January 2018

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

21 January 2018

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The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor

21 January 2018

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Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis

21 January 2018

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Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

21 January 2018

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21 January 2018

Identifiers

DOI

1 reference

13 May 2018

PubMed ID

19845770

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13 May 2018