Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (Q28294477)

Nature Reviews Immunology

Europe PubMed Central

title

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (English)

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author name string

Hiroshi Takayanagi

series ordinal

1

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language of work or name

English

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publication date

April 2007

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published in

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volume

7

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page(s)

292-304

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issue

4

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cites work

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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.

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PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.

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SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

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Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

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Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts

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TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis

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Osteoclasts are essential for TNF-alpha-mediated joint destruction

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Activated T lymphocytes support osteoclast formation in vitro

31 March 2020

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

31 March 2020

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

31 March 2020

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Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

31 March 2020

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T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy.

31 March 2020

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Postmenopausal osteoporosis, T cells, and immune dysfunction

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Conditional ablation of the osteoblast lineage in Col2.3deltatk transgenic mice

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Wnt signaling in the stem cell niche

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Cellular niches controlling B lymphocyte behavior within bone marrow during development.

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Denosumab in postmenopausal women with low bone mineral density

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Interleukin 6: from bench to bedside

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