Tau protein liquid-liquid phase separation can initiate tau aggregation. (Q53395943)

13 May 2018

title

Tau protein liquid-liquid phase separation can initiate tau aggregation. (English)

1 reference

13 May 2018

Pawel R Laskowski

7

0 references

Simon Dujardin

Simon Dujardin

6

0 references

Daniel Jobst Muller

Daniel Muller

16

0 references

Eckhard Mandelkow

18

Eckhard Mandelkow

1 reference

13 May 2018

Charles Vanderburg

11

0 references

Bradley Hyman

20

Bradley T Hyman

1 reference

13 May 2018

Susanne Wegmann

1

1 reference

13 May 2018

Bahareh Eftekharzadeh

2

1 reference

13 May 2018

Katharina Tepper

3

1 reference

13 May 2018

Katarzyna M Zoltowska

4

1 reference

13 May 2018

Rachel E Bennett

5

1 reference

13 May 2018

Danny MacKenzie

8

1 reference

13 May 2018

Tarun Kamath

9

1 reference

13 May 2018

Caitlin Commins

10

1 reference

13 May 2018

Allyson D Roe

12

1 reference

13 May 2018

Zhanyun Fan

13

1 reference

13 May 2018

Amandine M Molliex

14

1 reference

13 May 2018

Amayra Hernandez-Vega

15

1 reference

13 May 2018

Anthony A Hyman

17

1 reference

13 May 2018

J Paul Taylor

19

1 reference

13 May 2018

language of work or name

English

0 references

publication date

22 February 2018

1 reference

13 May 2018

published in

The EMBO Journal

1 reference

13 May 2018

volume

37

1 reference

13 May 2018

issue

7

1 reference

13 May 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5881631/fullTextXML

inferred from PubMed Central ID database lookup

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Mechanisms of protein seeding in neurodegenerative diseases

22 May 2018

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The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

22 May 2018

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The neuropathology and neurobiology of traumatic brain injury

22 May 2018

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Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels

22 May 2018

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

22 May 2018

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Phase transitions in the assembly of multivalent signalling proteins

22 May 2018

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Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.

22 May 2018

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

22 May 2018

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Droplets formation and merging in two-phase flow microfluidics

22 May 2018

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

22 May 2018

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Proteolytic processing of tau.

22 May 2018

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Caspase activation precedes and leads to tangles

22 May 2018

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ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

22 May 2018

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Structural polymorphism of 441-residue tau at single residue resolution

22 May 2018

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22 May 2018

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Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

22 May 2018

1 reference

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Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.

22 May 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Tau phosphorylation: physiological and pathological consequences

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Tau pathology in Alzheimer disease and other tauopathies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Tau aggregation is driven by a transition from random coil to beta sheet structure

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Tau phosphorylation in neuronal cell function and dysfunction

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Post-translational modifications of tau protein in Alzheimer's disease

22 May 2018

1 reference

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MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

22 May 2018

1 reference

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Staging of Alzheimer's disease-related neurofibrillary changes

22 May 2018

1 reference

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How crowded is the cytoplasm?

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

The dissociation of proteins by chaotropic salts.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

The primary structure and heterogeneity of tau protein from mouse brain

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Removal of the projections from cytoplasmic microtubules in vitro by digestion with trypsin

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Radioimmunoassay for tubulin: a quantitative comparison of the tubulin content of different established tissue culture cells and tissues

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Germline P granules are liquid droplets that localize by controlled dissolution/condensation

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

The "jaws" of the tau-microtubule interaction.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Characteristics of the binding of thioflavin S to tau paired helical filaments.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Global hairpin folding of tau in solution

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Regions of tau implicated in the paired helical fragment core as defined by NMR.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Proteolysis of non-phosphorylated and phosphorylated tau by thrombin

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Nonsaturable binding indicates clustering of tau on the microtubule surface in a paired helical filament-like conformation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5881631

Domains of tau protein and interactions with microtubules

13 August 2018

1 reference

12 December 2020

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

12 December 2020

Structural and microtubule binding properties of tau mutants of frontotemporal dementias

1 reference

12 December 2020

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

1 reference

12 December 2020

Identifiers

DOI

10.15252/EMBJ.201798049

1 reference

13 May 2018

PMC publication ID

5881631

1 reference

13 May 2018

PubMed publication ID

29472250

1 reference

13 May 2018