Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA). (Q53441592)

14 May 2018

title

Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA). (English)

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14 May 2018

author

Hiromu Kashida

5

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14 May 2018

author name string

Yukiko Kamiya

1

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14 May 2018

Junya Takai

2

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14 May 2018

Hiroshi Ito

3

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14 May 2018

Keiji Murayama

4

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14 May 2018

Hiroyuki Asanuma

6

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14 May 2018

publication date

18 September 2014

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14 May 2018

published in

ChemBioChem

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volume

15

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issue

17

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page(s)

2549-2555

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference

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Efficacy of a novel class of RNA interference therapeutic agents

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Highly potent and stable capped siRNAs with picomolar activity for RNA interference

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Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

21 January 2018

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Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

21 January 2018

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RNA interference with 2',4'-bridged nucleic acid analogues

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Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Exploring directional invasion of serum nuclease into siRNA duplexes by asymmetrical terminal modifications

21 January 2018

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Incorporation of biaryl units into the 5' and 3' ends of sense and antisense strands of siRNA duplexes improves strand selectivity and nuclease resistance

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

21 January 2018

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Improving the efficiency of RNA interference in mammals

21 January 2018

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Modulation of thermal stability can enhance the potency of siRNA

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Improved siRNA/shRNA functionality by mismatched duplex

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

21 January 2018

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Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

21 January 2018

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Improvement of RNAi activity and strand selectivity of RISC formation by modified siRNA involving intercalators near 5' termini

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The Crystal Structure of Human Argonaute2

21 January 2018

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The Structure of Human Argonaute-2 in Complex with miR-20a

21 January 2018

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The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs

21 January 2018

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Single processing center models for human Dicer and bacterial RNase III

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

Silencing activity of 2′-O-methyl modified anti-MDR1 siRNAs with mismatches in the central part of the duplexes

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201402369

21 January 2018

Identifiers

DOI

10.1002/CBIC.201402369

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14 May 2018

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14 May 2018