Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3). (Q53476537)

14 May 2018

title

Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3). (English)

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14 May 2018

author name string

Isabelle Carrier

series ordinal

1

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14 May 2018

Philippe Gros

series ordinal

2

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14 May 2018

language of work or name

English

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publication date

16 May 2008

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14 May 2018

published in

FEBS Journal

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14 May 2018

volume

275

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14 May 2018

issue

13

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14 May 2018

page(s)

3312-3324

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14 May 2018

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

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The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

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Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

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Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues

21 January 2018

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Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein

21 January 2018

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Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

21 January 2018

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Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway

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Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

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Validation of cystic fibrosis mutation analysis using ABI 3130XL genetic analyzer

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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10.1111/J.1742-4658.2008.06479.X

21 January 2018

Identifiers

DOI

1 reference

14 May 2018

1 reference

14 May 2018