Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. (Q36386127)

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16 January 2020

review article

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title

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux (English)

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16 January 2020

1

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16 January 2020

author name string

D M Clarke

series ordinal

2

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16 January 2020

publication date

1 August 2005

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16 January 2020

number of pages

13

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Journal of Membrane Biology

inferred from page(s)

published in

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16 January 2020

volume

206

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16 January 2020

issue

3

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16 January 2020

page(s)

173-185

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https://scigraph.springernature.com/pub.10.1007/s00232-005-0792-1

16 January 2020

exact match

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cites work

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

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Structure-activity relationships of multidrug resistance reversers

21 January 2018

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Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore

21 January 2018

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

21 January 2018

1 reference

12 December 2020

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

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12 December 2020

Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein

1 reference

12 December 2020

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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12 December 2020

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

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12 December 2020

Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

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12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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12 December 2020

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

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12 December 2020

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

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12 December 2020

QSAR studies on P-glycoprotein-regulated multidrug resistance and on its reversal by phenothiazines

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12 December 2020

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1 reference

12 December 2020

The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.

1 reference

12 December 2020

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

1 reference

12 December 2020

Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"?

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12 December 2020

Crystal structure of the transcription activator BmrR bound to DNA and a drug

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12 December 2020

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis

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12 December 2020

Characterization of the azidopine and vinblastine binding site of P-glycoprotein

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12 December 2020

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance

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12 December 2020

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

1 reference

12 December 2020

Structural mechanisms of QacR induction and multidrug recognition

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12 December 2020

Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump

1 reference

12 December 2020

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models

1 reference

12 December 2020

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

1 reference

12 December 2020

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

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12 December 2020

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

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12 December 2020

The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

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12 December 2020

Both P-glycoprotein nucleotide-binding sites are catalytically active

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12 December 2020

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

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12 December 2020

P-glycoprotein and multidrug resistance protein activities in relation to treatment outcome in acute myeloid leukemia.

1 reference

12 December 2020

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

1 reference

12 December 2020

Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study

1 reference

12 December 2020

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

12 December 2020

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

12 December 2020

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

1 reference

12 December 2020

Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation

1 reference

12 December 2020

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

12 December 2020

Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

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12 December 2020

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12.

1 reference

12 December 2020

FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

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12 December 2020

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

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12 December 2020

Crystal structure of bacterial multidrug efflux transporter AcrB

1 reference

12 December 2020

Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity.

1 reference

12 December 2020

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

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12 December 2020

Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors

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12 December 2020

The human ATP-binding cassette (ABC) transporter superfamily

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12 December 2020

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

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12 December 2020

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides

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12 December 2020

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

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12 December 2020

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

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12 December 2020

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

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12 December 2020

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein

1 reference

12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Both ATP sites of human P-glycoprotein are essential but not symmetric

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12 December 2020

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

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12 December 2020

Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

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12 December 2020

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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12 December 2020

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

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12 December 2020

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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12 December 2020

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

1 reference

12 December 2020

Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane

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12 December 2020

Localization of the iodomycin binding site in hamster P-glycoprotein

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12 December 2020

The catalytic cycle of P-glycoprotein

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Increased drug permeability in Chinese hamster ovary cells in the presence of cyanide.

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12 December 2020

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

1 reference

12 December 2020

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

12 December 2020

Is the multidrug transporter a flippase?

1 reference

12 December 2020

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

12 December 2020

A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

1 reference

12 December 2020

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1 reference

12 December 2020

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

1 reference

12 December 2020

Improved energy coupling of human P-glycoprotein by the glycine 185 to valine mutation

1 reference

12 December 2020

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

12 December 2020

The multidrug transporter, a double-edged sword

1 reference

12 December 2020

Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly

1 reference

12 December 2020

Isolation and expression of a complementary DNA that confers multidrug resistance

1 reference

12 December 2020

A multidrug resistance transporter from human MCF-7 breast cancer cells

1 reference

12 December 2020

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1 reference

12 December 2020

The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

1 reference

12 December 2020

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

1 reference

12 December 2020

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

1 reference

12 December 2020

Structural basis of energy transduction in the transport cycle of MsbA.

1 reference

12 December 2020

Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein

1 reference

12 December 2020

Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

1 reference

12 December 2020

RETRACTED: Structure of the ABC transporter MsbA in complex with ADP.vanadate and lipopolysaccharide

1 reference

12 December 2020

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin

1 reference

12 December 2020

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates

1 reference

12 December 2020

P-glycoprotein: from genomics to mechanism.

1 reference

12 December 2020

ABC Transporters: From Microorganisms to Man

1 reference

12 December 2020

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

1 reference

12 December 2020

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

1 reference

12 December 2020

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

12 December 2020

A general pattern for substrate recognition by P-glycoprotein.

1 reference

12 December 2020

Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

1 reference

12 December 2020

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

1 reference

12 December 2020

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

12 December 2020

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

1 reference

12 December 2020

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein

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12 December 2020

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

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12 December 2020

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

12 December 2020

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo

1 reference

12 December 2020

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

12 December 2020

A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator

1 reference

12 December 2020

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies

1 reference

12 December 2020

Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

1 reference

12 December 2020

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance

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12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

12 December 2020

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

12 December 2020

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

1 reference

12 December 2020

Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

1 reference

12 December 2020

Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

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12 December 2020

Reduced permeability in CHO cells as a mechanism of resistance to colchicine.

1 reference

12 December 2020

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

1 reference

12 December 2020

Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

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12 December 2020

Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues

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12 December 2020

P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy

1 reference

12 December 2020

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

12 December 2020

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

12 December 2020

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

1 reference

12 December 2020

Identification of the cyclosporin-binding site in P-glycoprotein

1 reference

12 December 2020

Characterization of two pharmacophores on the multidrug transporter P-glycoprotein

1 reference

12 December 2020

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

1 reference

12 December 2020

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein

1 reference

12 December 2020

The minimum functional unit of human P-glycoprotein appears to be a monomer.

1 reference

12 December 2020

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein

1 reference

12 December 2020

ATP hydrolysis promotes interactions between the extracellular ends of transmembrane segments 1 and 11 of human multidrug resistance P-glycoprotein.

1 reference

12 December 2020

Genetic polymorphisms of the human MDR1 drug transporter

1 reference

12 December 2020

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

1 reference

12 December 2020

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

1 reference

12 December 2020

Genetic and biochemical characterization of multidrug resistance

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12 December 2020

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

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12 December 2020

Proximity of bound Hoechst 33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells

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12 December 2020

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

1 reference

12 December 2020

Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.

1 reference

12 December 2020

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

12 December 2020

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

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12 December 2020

CFTR is a monomer: biochemical and functional evidence

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12 December 2020

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

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12 December 2020

Structure and function of efflux pumps that confer resistance to drugs

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12 December 2020

Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopy

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12 December 2020

10.1007/S00232-005-0792-1

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16456713%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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