Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. (Q53542852)

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English	Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.	scientific article

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1 January 2020

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation (English)

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C Iacobini

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C Ricci

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G Oddi

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C Pesce

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F Pugliese

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K Block

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H E Abboud

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E Migliaccio

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P G Pelicci

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G Pugliese

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publication date

5 July 2007

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50

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9

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1997-2007

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1 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-007-0728-7

0 references

The metabolic syndrome and chronic kidney disease in U.S. adults

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0728-7

21 January 2018

Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship to oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end product receptor-mediated cellular dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sos-mediated activation of rac1 by p66shc

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes and advanced glycoxidation end products.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation endproducts promote adhesion molecule (VCAM-1, ICAM-1) expression and atheroma formation in normal rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathobiology of diabetic complications: a unifying mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and antioxidant treatment in hypertension and the associated renal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycoxidation and lipoxidation in atherogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor-kappa B (NF-kappa B) and renal disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentosidine: A molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p66ShcA modulates tissue response to hindlimb ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage to mitochondria and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo: evidence on the role of lipids in chemical modification of protein and development of diabetic complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of p66shc gene protects against age-related endothelial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-fat diet enhances visceral advanced glycation end products, nuclear O-Glc-Nac modification, p38 mitogen-activated protein kinase activation and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17611735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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