Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus. (Q53555792)

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English	Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.	scientific article

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scholarly article

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus. (English)

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

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based on heuristic

inferred from title

Streptomyces hygroscopicus

object named as

Streptomyces hygroscopicus

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based on heuristic

inferred from title

metabolic profiling

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author name string

Baohua Wang

1

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Jiao Liu

2

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Huanhuan Liu

3

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Di Huang

4

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Jianping Wen

5

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

publication date

4 April 2015

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Journal of Industrial Microbiology & Biotechnology

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

42

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

6

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

949-963

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin

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Reference gene validation for quantitative RT-PCR during biotic and abiotic stresses in Vitis vinifera

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Generation of high-yield rapamycin-producing strains through protoplasts-related techniques

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Metabolite profiling of CHO cells with different growth characteristics.

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Incorporation of amino acid-derived carbon into tylactone by Streptomyces fradiae GS14.

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Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster

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Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production

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A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

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Valine is a precursor of propionyl-CoA

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A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain

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Analyzing real-time PCR data by the comparative C(T) method

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Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae

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Regulation of tacrolimus production by altering primary source of carbons and amino acids.

1 reference

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Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.

1 reference

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21 January 2018

Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae

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Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase.

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Intracellular Metabolite Pool Changes in Response to Nutrient Depletion Induced Metabolic Switching in Streptomyces coelicolor

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Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

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A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.

1 reference

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Metabolic profiling of a Rhizopus oryzae fumaric acid production mutant generated by femtosecond laser irradiation

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Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus

1 reference

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Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.

1 reference

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Assessment of adaptive focused acoustics versus manual vortex/freeze-thaw for intracellular metabolite extraction from Streptomyces lividans producing recombinant proteins using GC-MS and multi-block principal component analysis

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Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum

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Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis

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Production of rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology

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Rapamycin for immunosuppression in organ allografting.

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Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

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Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904.

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Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus

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Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus

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Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus

1 reference

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Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

1 reference

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

10.1007/S10295-015-1611-Z

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/25840873

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