Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. (Q53592062)

16 May 2018

title

Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. (English)

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16 May 2018

Pascal J Goldschmidt-Clermont

author

9

object named as

Pascal J Goldschmidt-Clermont

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16 May 2018

author name string

Steve S Choi

1

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16 May 2018

Jason K Sicklick

2

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16 May 2018

Qi Ma

3

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16 May 2018

Liu Yang

4

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16 May 2018

Jiawen Huang

5

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16 May 2018

Yi Qi

6

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16 May 2018

Wei Chen

7

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16 May 2018

Yin-Xiong Li

8

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16 May 2018

Anna Mae Diehl

10

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16 May 2018

language of work or name

English

0 references

publication date

1 November 2006

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16 May 2018

published in

Hepatology

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16 May 2018

volume

44

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16 May 2018

issue

5

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16 May 2018

page(s)

1267-1277

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16 May 2018

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

cites work

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NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

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NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells

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Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair

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Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.

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7 January 2021

Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells.

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7 January 2021

Role for hedgehog signaling in hepatic stellate cell activation and viability

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7 January 2021

Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1(I) and alpha1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs.

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Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by northern hybridization analysis

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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells

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Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy

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A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections

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Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells

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7 January 2021

Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells

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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

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7 January 2021

Expression of platelet-derived growth factor in a model of acute liver injury

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Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture

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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

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Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

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Cytoskeleton of liver perisinusoidal cells (lipocytes) in normal and pathological conditions

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Inhibition of migration and proliferation of rat vascular smooth muscle cells by a new HMG-CoA reductase inhibitor, pitavastatin

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Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27.

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.21375

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16 May 2018

release_6x2x5kxb3nck7ftmmsbfvrycv4

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/6x2x5kxb3nck7ftmmsbfvrycv4

24 November 2022

mapped directly with Wikidata item

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16 May 2018