Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf. (Q53605317)

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28 December 2019

title

Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf (English)

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28 December 2019

1

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Pawel Krzysztof Wlodarski

28 December 2019

5

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28 December 2019

author name string

Kasprzycka M

2

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28 December 2019

Liu X

3

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28 December 2019

Raghunath PN

4

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28 December 2019

Wasik MA

6

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28 December 2019

language of work or name

English

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publication date

7 August 2006

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28 December 2019

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28 December 2019

volume

26

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28 December 2019

issue

6

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28 December 2019

page(s)

813-821

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209843

28 December 2019

exact match

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cites work

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

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NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.

21 January 2018

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

21 January 2018

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Identification of NPM-ALK interacting proteins by tandem mass spectrometry.

21 January 2018

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Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 January 2018

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

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Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library

21 January 2018

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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

21 January 2018

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

21 January 2018

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ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

21 January 2018

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Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

21 January 2018

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Map kinase signaling pathways and hematologic malignancies

21 January 2018

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ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

21 January 2018

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Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway

21 January 2018

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The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

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Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

21 January 2018

1 reference

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MEK1 and MEK2, different regulators of the G1/S transition.

21 January 2018

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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

21 January 2018

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Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway

21 January 2018

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Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.

21 January 2018

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Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

21 January 2018

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

21 January 2018

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ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL).

21 January 2018

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7 January 2021

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209843

7 January 2021

Molecular aspects of multiple myeloma

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7 January 2021

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209843

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209843

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16909118%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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