The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. (Q53622050)

16 May 2018

title

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. (English)

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16 May 2018

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Joona Valtonen

object named as

Joona Valtonen

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Sirpa Jalkanen

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Sirpa Jalkanen

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author name string

Kaisa Auvinen

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Norma Jäppinen

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Maria Kapraali

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Marika Karikoski

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Heidi Gerke

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Imtiaz Iftakhar-E-Khuda

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Johannes Keuschnigg

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Eiji Umemoto

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Kazuo Tohya

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Masayuki Miyasaka

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Kati Elima

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Marko Salmi

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language of work or name

English

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publication date

9 February 2015

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16 May 2018

published in

Nature Immunology

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volume

16

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16 May 2018

page(s)

386-396

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issue

4

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16 May 2018

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

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Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex

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The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

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A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission.

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PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1.

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Interstitial dendritic cell guidance by haptotactic chemokine gradients

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12 December 2020

Monoclonal antibody PAL-E specific for endothelium

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Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration

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Lectin analysis of common glycoproteins detected on the surface of continuous microvascular endothelium in situ and in culture: identification of sialoglycoproteins

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Overall architecture and pattern of lymph flow in the rat lymph node

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Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity

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Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice

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Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

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12 December 2020

The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.3101

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16 May 2018

PubMed ID

25665101

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16 May 2018