Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. (Q53675615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15897874%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX (English)

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11 January 2020

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4

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11 January 2020

author name string

Nolan R Filipenko

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15897874%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Sarah Attwell

series ordinal

2

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11 January 2020

Calvin Roskelley

series ordinal

3

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11 January 2020

language of work or name

English

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publication date

1 September 2005

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11 January 2020

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11 January 2020

volume

24

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11 January 2020

issue

38

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11 January 2020

page(s)

5837-5849

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208737

11 January 2020

exact match

0 references

cites work

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The integrin-linked kinase (ILK) suppresses anoikis

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Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods.

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The integrin-actin connection, an eternal love affair

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Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination

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Integrin-mediated signals regulated by members of the rho family of GTPases

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Cell-substrate interactions and signaling through ILK

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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Integrin signaling to the actin cytoskeleton.

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PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

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Integrin-linked kinase regulates chondrocyte shape and proliferation

21 January 2018

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Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

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Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

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Role of the PI3K regulatory subunit in the control of actin organization and cell migration

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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

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The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor

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Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

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Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

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Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.

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Cell migration: Rho GTPases lead the way

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Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

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Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

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A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

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The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

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Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

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Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain

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Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

21 January 2018

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Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration

21 January 2018

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Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

21 January 2018

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Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival

21 January 2018

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

21 January 2018

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7 January 2021

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Role of integrin-linked kinase in nerve growth factor-stimulated neurite outgrowth

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208737