Integrin-linked kinase: a cancer therapeutic target unique among its ILK. (Q35998768)

11 August 2017

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title

Integrin-linked kinase: a cancer therapeutic target unique among its ILK. (English)

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11 August 2017

Gregory Hannigan

1

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11 August 2017

Armelle A Troussard

series ordinal

2

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11 August 2017

Shoukat Dedhar

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

1 January 2005

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11 August 2017

Nature Reviews Cancer

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11 August 2017

5

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11 August 2017

51-63

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11 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrc1524

11 August 2017

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cites work

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

1 reference

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

31 March 2020

1 reference

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

31 March 2020

1 reference

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

31 March 2020

1 reference

The integrin-actin connection, an eternal love affair

31 March 2020

1 reference

The PINCH-ILK-parvin complexes: assembly, functions and regulation.

31 March 2020

1 reference

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

31 March 2020

1 reference

Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction

31 March 2020

1 reference

Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation.

31 March 2020

1 reference

The role of integrin-linked kinase (ILK) in cancer progression

31 March 2020

1 reference

Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.

31 March 2020

1 reference

Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase

31 March 2020

1 reference

ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells.

31 March 2020

1 reference

Integrin-linked kinase regulates endothelial cell survival and vascular development.

31 March 2020

1 reference

Regulation of tumor angiogenesis by integrin-linked kinase (ILK).

31 March 2020

1 reference

Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor

31 March 2020

1 reference

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

31 March 2020

1 reference

Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

31 March 2020

1 reference

Integrin signaling to the actin cytoskeleton.

31 March 2020

1 reference

Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out).

31 March 2020

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Mechanotransduction across the cell surface and through the cytoskeleton

31 March 2020

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Dual control of cell growth by somatomedins and platelet-derived growth factor

31 March 2020

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Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown

31 March 2020

1 reference

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins

31 March 2020

1 reference

Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4

31 March 2020

1 reference

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

31 March 2020

1 reference

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.

31 March 2020

1 reference

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

31 March 2020

1 reference

A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

31 March 2020

1 reference

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

31 March 2020

1 reference

The protein kinase complement of the human genome

31 March 2020

1 reference

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

31 March 2020

1 reference

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

31 March 2020

1 reference

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

31 March 2020

1 reference

Integrin adhesion: when is a kinase a kinase?

31 March 2020

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The integrin-linked kinase (ILK) suppresses anoikis

31 March 2020

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Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

31 March 2020

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Integrin-linked kinase is a positive mediator of L6 myoblast differentiation

31 March 2020

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Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.

31 March 2020

1 reference

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

1 reference

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

31 March 2020

1 reference

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.

31 March 2020

1 reference

alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells

31 March 2020

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

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PTEN: The down side of PI 3-kinase signalling.

31 March 2020

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

31 March 2020

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

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The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

31 March 2020

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Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

31 March 2020

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Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.

31 March 2020

1 reference

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer

31 March 2020

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Down-Regulation of DOC-2 in Colorectal Cancer Points to Its Role as a Tumor Suppressor in This Malignancy

31 March 2020

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Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas

31 March 2020

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Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.

31 March 2020

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Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge

31 March 2020

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Spatial localization of mono-and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells

31 March 2020

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Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cells

31 March 2020

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Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase

31 March 2020

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Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases

31 March 2020

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A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration

31 March 2020

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Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain

31 March 2020

1 reference

PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

31 March 2020

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Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration

31 March 2020

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PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

31 March 2020

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Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization

31 March 2020

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Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer

31 March 2020

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CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

31 March 2020

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Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival

31 March 2020

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Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

31 March 2020

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Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex

31 March 2020

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Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

31 March 2020

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Disruption of epithelial cell-matrix interactions induces apoptosis

31 March 2020

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A link between cyclin A expression and adhesion-dependent cell cycle progression

31 March 2020

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Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

31 March 2020

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The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

31 March 2020

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Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase

31 March 2020

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Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes

31 March 2020

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Integrin-linked kinase regulates chondrocyte shape and proliferation

31 March 2020

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Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner

31 March 2020

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ILKAP regulates ILK signaling and inhibits anchorage-independent growth

31 March 2020

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Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency

31 March 2020

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

31 March 2020

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Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons

31 March 2020

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The protein kinase B/Akt signalling pathway in human malignancy

31 March 2020

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Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner

31 March 2020

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Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway

31 March 2020

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Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis

31 March 2020

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Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

31 March 2020

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

31 March 2020

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Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination

31 March 2020

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

31 March 2020

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Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

31 March 2020

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Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

31 March 2020

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Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

31 March 2020

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Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells

31 March 2020

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Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition

31 March 2020

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

31 March 2020

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The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).

31 March 2020

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Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

31 March 2020

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Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase

31 March 2020

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Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.

31 March 2020

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Integrin-linked kinase (ILK) expression in human colon cancer

31 March 2020

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Characterisation of integrin-linked kinase signalling in sporadic human colon cancer

31 March 2020

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Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis

31 March 2020

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Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid

31 March 2020

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Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma

31 March 2020

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ILK (beta1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour

31 March 2020

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Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase

31 March 2020

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Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.

31 March 2020

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PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

31 March 2020

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Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

31 March 2020

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Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

31 March 2020

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Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

31 March 2020

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Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity.

31 March 2020

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Integrin-linked kinase (ILK) in combination molecular targeting.

31 March 2020

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

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C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo

31 March 2020

1 reference

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1524

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Dimensions Publication ID

11 August 2017

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