Eukaryotic translation termination factor 1 (Q5408693)

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mammalian protein found in Homo sapiens

ETF1
TB3-1
polypeptide chain release factor 1
sup45 (yeast omnipotent suppressor 45) homolog-like 1
eukaryotic peptide chain release factor subunit 1
protein Cl1

Language	Label	Description	Also known as
English	Eukaryotic translation termination factor 1	mammalian protein found in Homo sapiens	ETF1 TB3-1 polypeptide chain release factor 1 sup45 (yeast omnipotent suppressor 45) homolog-like 1 eukaryotic peptide chain release factor subunit 1 protein Cl1

Statements

1 reference

13 November 2019

UniProt protein ID

Peptide chain release factor eRF1/aRF1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

Peptide Chain Release Factor eRF1/aRF1, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

50S ribosomal protein L30e-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

eRF1 domain 1/Pelota-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

eRF1 domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

eRF1 domain 3, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ribosome binding

determination method

1 reference

8 April 2019

Eukaryotic release factors (eRFs) history

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

translation termination factor activity

determination method

1 reference

26 September 2017

Human release factor eRF1: structural organisation of the unique functional gene on chromosome 5 and of the three processed pseudogenes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62495&geneProductId=UniProtKB:P62495

determination method

protein binding

determination method

7 references

8 April 2019

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Defining the human deubiquitinating enzyme interaction landscape

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

sequence-specific mRNA binding

determination method

1 reference

26 September 2017

Stop codons and UGG promote efficient binding of the polypeptide release factor eRF1 to the ribosomal A site

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62495&geneProductId=UniProtKB:P62495

determination method

translation release factor activity

determination method

3 references

8 April 2019

The effect of eukaryotic release factor depletion on translation termination in human cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

translation termination factor activity

determination method

translation release factor activity, codon specific

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

determination method

5 references

8 April 2019

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

8 April 2019

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62495&geneProductId=UniProtKB:P62495

determination method

determination method

1 reference

8 April 2019

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

translation release factor complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

biological process

translational termination

determination method

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62495&geneProductId=UniProtKB:P62495

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62495&geneProductId=UniProtKB:P62495

determination method

regulation of translational termination

determination method

1 reference

8 April 2019

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

protein methylation

determination method

1 reference

8 April 2019

HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

protein biosynthesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

cytoplasmic translational termination

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

translational termination

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62495

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

eRF1 domain 1/Pelota-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62495

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353741

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353741

ENSP00000421288

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421288

ENSP00000422203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422203

ENSP00000422272

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422272

ENSP00000425689

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425689

ENSP00000461082

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461082

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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