Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89. (Q54117221)

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scientific article published in November 1998

Language	Label	Description	Also known as
English	Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.	scientific article published in November 1998

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89. (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

author name string

Tong Y

1

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Liu-Chen X

2

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Ercikan-Abali EA

3

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Zhao SC

4

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Banerjee D

5

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Maley F

6

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

Bertino JR

7

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

language of work or name

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publication date

1 November 1998

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

number of pages

6

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

273

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25 May 2018

http://europepmc.org/abstract/MED/9813027

47

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

31209-31214

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Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

describes a project that uses

site-directed mutagenesis

1 reference

based on heuristic

inferred from title

Atomic structure of thymidylate synthase: target for rational drug design

1 reference

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Folate-based thymidylate synthase inhibitors as anticancer drugs

1 reference

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The catalytic mechanism and structure of thymidylate synthase

1 reference

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Structure-based discovery of inhibitors of thymidylate synthase

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The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice

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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

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Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate

1 reference

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Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism

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Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei

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Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A

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Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

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The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition

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Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89

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Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1 reference

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21 January 2018

Design of enzyme inhibitors using iterative protein crystallographic analysis

1 reference

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Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase

1 reference

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21 January 2018

Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis

1 reference

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21 January 2018

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

1 reference

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21 January 2018

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

1 reference

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21 January 2018

High-level expression of human thymidylate synthase.

1 reference

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21 January 2018

Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate

1 reference

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21 January 2018

Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases.

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21 January 2018

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase

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21 January 2018

Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors

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21 January 2018

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

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21 January 2018

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis

1 reference

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21 January 2018

Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.47.31209

21 January 2018

Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.

1 reference

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21 January 2018

Resistance mechanisms to methotrexate in tumors.

1 reference

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21 January 2018

Enhancement of thymidylate synthase inhibition.

1 reference

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21 January 2018

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1 reference

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21 January 2018

Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate

1 reference

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Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase

1 reference

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21 January 2018

Identifiers

10.1074/JBC.273.47.31209

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 May 2018

http://europepmc.org/abstract/MED/9813027

ResearchGate publication ID

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