Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis. (Q54292098)

27 May 2018

title

Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis. (English)

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27 May 2018

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Seung-Ki Kwok

1

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27 May 2018

Mi-La Cho

2

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Mi-Kyung Park

3

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Hye-Joa Oh

4

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Jin-Sil Park

5

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Yang-Mi Her

6

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Seon-Yeong Lee

7

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Jeehee Youn

8

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Ji Hyeon Ju

9

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Kyung Su Park

10

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Sung-Il Kim

11

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Ho-Youn Kim

12

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Sung-Hwan Park

13

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publication date

1 March 2012

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27 May 2018

published in

Arthritis and Rheumatism

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volume

64

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page(s)

740-751

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issue

3

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Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

cites work

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Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts

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Osteoimmunology: cytokines and the skeletal system

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

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IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

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IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model

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Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes

21 January 2018

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Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis

21 January 2018

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A critical role for IL-21 in regulating immunoglobulin production

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Interleukin 21 as a target of intervention in autoimmune disease

21 January 2018

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IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

21 January 2018

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Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

21 January 2018

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

21 January 2018

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Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis

21 January 2018

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A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.

21 January 2018

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Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.

21 January 2018

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The course of radiologic damage during the first six years of rheumatoid arthritis.

21 January 2018

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Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis

21 January 2018

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Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage

21 January 2018

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Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group

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Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

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Identifiers

DOI

10.1002/ART.33390

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27 May 2018

PubMed ID

21968544

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27 May 2018