Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation. (Q54311139)

27 May 2018

title

Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation. (English)

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27 May 2018

author name string

Ai Q Li

1

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27 May 2018

Liang Zhao

2

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27 May 2018

Teng F Zhou

3

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27 May 2018

Meng Q Zhang

4

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27 May 2018

Xiao M Qin

5

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27 May 2018

publication date

5 November 2014

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27 May 2018

American Journal of Physiology - Cell Physiology

published in

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27 May 2018

volume

308

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27 May 2018

page(s)

C164-75

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27 May 2018

issue

2

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27 May 2018

Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Endothelial cell-cell junctions: happy together

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Glucagon-like peptide-1 preserves coronary microvascular endothelial function after cardiac arrest and resuscitation: potential antioxidant effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Incretin-based therapies for type 2 diabetes mellitus: current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Exendin-4 alleviates retinal vascular leakage by protecting the blood-retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Insulin plus incretin agent combination therapy in type 2 diabetes: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Mechanotransduction at the basis of endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

VE-cadherin: at the front, center, and sides of endothelial cell organization and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: results from an observational research

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Regulation of endothelial permeability via paracellular and transcellular transport pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

cAMP signaling in leukocyte transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

The cardiovascular safety of incretin-based therapies: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier- a signaling pathway compromised in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

VE-cadherin phosphorylation decides: vascular permeability or diapedesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Ultrastructural analysis reveals cAMP-dependent enhancement of microvascular endothelial barrier functions via Rac1-mediated reorganization of intercellular junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00249.2014

10.1152/AJPCELL.00249.2014

21 January 2018

Identifiers

DOI

1 reference

27 May 2018

PubMed ID

25377089

1 reference

27 May 2018