Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. (Q54332931)

27 May 2018

title

Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model. (English)

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4

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author name string

Haruei Ogino

1

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Kazuhiko Nakamura

2

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Tsutomu Iwasa

3

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Hirotada Akiho

5

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Yasuaki Motomura

6

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Kazuya Akahoshi

7

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Hisato Igarashi

8

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Masaki Kato

9

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Kazuhiro Kotoh

10

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Tetsuhide Ito

11

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Ryoichi Takayanagi

12

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publication date

22 December 2011

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Journal of Gastroenterology

published in

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volume

47

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issue

4

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page(s)

366-376

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The fundamental basis of inflammatory bowel disease

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Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis

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Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells

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A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis

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Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

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T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

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Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity

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Preparation of functionally preserved CD4+ CD25high regulatory T cells from leukapheresis products from ulcerative colitis patients, applicable to regulatory T-cell transfer therapy

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CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells

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Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin

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Rapamycin: clinical results and future opportunities

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CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model

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Therapeutic effect of a new immunosuppressive agent, everolimus, on interleukin-10 gene-deficient mice with colitis

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Identifiers

DOI

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27 May 2018

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