FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination. (Q54333338)

27 May 2018

title

FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination. (English)

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27 May 2018

main subject

protein ubiquitination

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J D Choi

1

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27 May 2018

M Ryu

2

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27 May 2018

M Ae Park

3

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27 May 2018

G Jeong

4

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27 May 2018

J-S Lee

5

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27 May 2018

language of work or name

English

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publication date

2 July 2012

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27 May 2018

published in

Oncogene

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27 May 2018

volume

32

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27 May 2018

issue

19

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27 May 2018

page(s)

2421-2432

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27 May 2018

https://scigraph.springernature.com/pub.10.1038/onc.2012.262

exact match

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cites work

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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FIP200, a key signaling node to coordinately regulate various cellular processes

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Suppression of Pyk2 kinase and cellular activities by FIP200

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Regulation of focal adhesion kinase by a novel protein inhibitor FIP200

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Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control

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Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways

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Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells

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Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity

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Isolation, characterization and mapping of the mouse and human RB1CC1 genes

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Truncating mutations of RB1CC1 in human breast cancer

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Mechanism of cell cycle regulation by FIP200 in human breast cancer cells

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Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

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Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

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RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity

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A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage

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β-catenin is dynamically stored and cleared in multiple myeloma by the proteasome-aggresome-autophagosome-lysosome pathway.

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

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Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration

21 January 2018

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FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

21 January 2018

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RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer

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Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models

21 January 2018

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Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL

21 January 2018

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21 January 2018

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Acetyltransferase p300 regulates NBS1-mediated DNA damage response

21 January 2018

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SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy

21 January 2018

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

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Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2012.262

1 reference

27 May 2018

PubMed ID

22751121

1 reference

27 May 2018