Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production. (Q54399029)

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29 February 2020

title

Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production (English)

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29 February 2020

1

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29 February 2020

author name string

Hans J P M Koenen

2

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29 February 2020

Ruben L Smeets

3

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29 February 2020

Romy Keijsers

4

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29 February 2020

Esther van Rijssen

5

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29 February 2020

Andreas Koerber

6

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29 February 2020

Peter C van de Kerkhof

7

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29 February 2020

Annemieke M H Boots

8

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29 February 2020

Irma Joosten

9

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language of work or name

English

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publication date

5 November 2013

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Journal of Investigative Dermatology

29 February 2020

published in

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29 February 2020

volume

134

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29 February 2020

issue

4

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page(s)

975-983

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Protein kinase C-theta mediates negative feedback on regulatory T cell function

29 February 2020

cites work

1 reference

12 December 2020

Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation

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Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

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Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

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Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis

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12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

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CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells.

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Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.

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IL-17-producing human peripheral regulatory T cells retain suppressive function

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12 December 2020

DNA methylation controls Foxp3 gene expression

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12 December 2020

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

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12 December 2020

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

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12 December 2020

Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts

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The dark side of regulatory T cells in psoriasis

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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

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Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

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Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

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Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

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Differential requirement of PKC-theta in the development and function of natural regulatory T cells

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Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

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Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

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12 December 2020

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

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12 December 2020

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

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12 December 2020

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

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12 December 2020

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.

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12 December 2020

PKC-θ function at the immunological synapse: prospects for therapeutic targeting

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12 December 2020

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

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12 December 2020

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

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12 December 2020

Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.

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12 December 2020

Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin

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12 December 2020