P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer. (Q54403803)

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15 January 2020

title

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer (English)

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15 January 2020

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3

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15 January 2020

Juan C Montero

series ordinal

1

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15 January 2020

4

A Pandiella

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15 January 2020

author name string

S Seoane

series ordinal

2

1 reference

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15 January 2020

language of work or name

English

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publication date

1 November 2010

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15 January 2020

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15 January 2020

volume

30

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15 January 2020

issue

9

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15 January 2020

page(s)

1059-1071

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

15 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

21 January 2018

1 reference

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Critical update and emerging trends in epidermal growth factor receptor targeting in cancer

21 January 2018

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Role of heregulin in human cancer

21 January 2018

1 reference

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TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

P-Rex2, a new guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Molecular predictors of response to trastuzumab and lapatinib in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Identification of heregulin, a specific activator of p185erbB2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

21 January 2018

Neuregulins and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

Membrane-anchored growth factors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.489

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21042280%20AND%20SRC:MED&resulttype=core&format=json

release_iduga32wpfdztepvrce6cqczsm

15 January 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference