Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice. (Q54418168)

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8 February 2020

title

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice (English)

1 reference

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8 February 2020

4

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8 February 2020

Amanda Fosang

5

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8 February 2020

author name string

Fraser M Rogerson

1

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8 February 2020

Yuen M Chung

2

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8 February 2020

Michael E Deutscher

3

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8 February 2020

publication date

1 November 2010

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8 February 2020

published in

Arthritis and Rheumatism

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8 February 2020

volume

62

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8 February 2020

issue

11

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8 February 2020

page(s)

3365-3373

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Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.

8 February 2020

cites work

1 reference

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

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ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

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Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.

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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL

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TNF-induced structural joint damage is mediated by IL-1.

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A new mathematical model for relative quantification in real-time RT-PCR

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Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity

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Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M.

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Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

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Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

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n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation

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Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta

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Expression profiling of metalloproteinases and their inhibitors in cartilage

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MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

21 January 2018

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Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

21 January 2018

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An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients

21 January 2018

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ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.

21 January 2018

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NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells

21 January 2018

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Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

21 January 2018

1 reference