Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. (Q54453412)

30 May 2018

title

Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism. (English)

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30 May 2018

main subject

apigenin

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ChEBI release 2020-05-28

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Salida Mirzoeva

1

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30 May 2018

Carrie A Franzen

series ordinal

2

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30 May 2018

Jill C Pelling

series ordinal

3

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publication date

28 January 2013

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30 May 2018

published in

Molecular Carcinogenesis

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volume

53

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issue

8

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page(s)

598-609

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Prospective study of prostate tumor angiogenesis and cancer-specific mortality in the health professionals follow-up study

cites work

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Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

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Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.

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Apigenin: a promising molecule for cancer prevention

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Blockade of transforming growth factor-beta (TGFβ) signaling inhibits osteoblastic tumorigenesis by a novel human prostate cancer cell line

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The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism

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Inhibition of Src kinase activity by Ad-mda7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells

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c-Src and cooperating partners in human cancer

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HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

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Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

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Prostate cancer mediates osteoclastogenesis through two different pathways

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TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

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Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression

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Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.

21 January 2018

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Effect of flavonoids on cell cycle progression in prostate cancer cells

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Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1.

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Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells

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Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II.

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Targeting TGF-beta in prostate cancer: therapeutic possibilities during tumor progression

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21 January 2018

Identifiers

DOI

10.1002/MC.22005

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30 May 2018

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30 May 2018