Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. (Q54459192)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19824072%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload (English)

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9 February 2020

1

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9 February 2020

David M. Frazer

series ordinal

4

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9 February 2020

Gregory J Anderson

series ordinal

5

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9 February 2020

Nathan V Subramaniam

series ordinal

6

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9 February 2020

2

Lesa Summerville

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9 February 2020

3

Emily M Crampton

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9 February 2020

language of work or name

English

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publication date

1 December 2009

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9 February 2020

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9 February 2020

volume

50

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9 February 2020

issue

6

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9 February 2020

page(s)

1992-2000

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

9 February 2020

cites work

1 reference

7 January 2021

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

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7 January 2021

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

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Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent.

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New TFR2 mutations in young Italian patients with hemochromatosis

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7 January 2021

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

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7 January 2021

Hepcidin is decreased in TFR2 hemochromatosis

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7 January 2021

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

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7 January 2021

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

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7 January 2021

Hfe acts in hepatocytes to prevent hemochromatosis.

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7 January 2021

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

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7 January 2021

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

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7 January 2021

Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system.

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7 January 2021

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

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7 January 2021

Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes

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7 January 2021

Regulation of transferrin receptor 2 protein levels by transferrin

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7 January 2021

Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice.

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7 January 2021

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

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7 January 2021

Decreased liver hepcidin expression in the Hfe knockout mouse

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7 January 2021

Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway

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7 January 2021

Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.

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7 January 2021

Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis

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7 January 2021

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

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7 January 2021

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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7 January 2021

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

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7 January 2021

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

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7 January 2021

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1 reference

7 January 2021

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

1 reference

7 January 2021

The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells

1 reference

7 January 2021

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

1 reference

7 January 2021

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

1 reference

7 January 2021

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

1 reference

7 January 2021

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

1 reference

7 January 2021

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

1 reference

7 January 2021